FEATURES OF PHARMACOKINETICS OF ANTIPARASITIC DRUG "DEVIMEKTIN 1%" ON RABBITS

Abstract

One of the stages of pharmacokinetic studies of the antiparasitic drug ―Devimectin 1%‖ with the active ingredient ivermectin on rabbits was studied and the time frame for its removal from animals was established. There sults of research on the dynamics of the distribution of the content of "Deymectin 1%" in the case of double parenteral administration of the minimum the rapeutic dose sindicate a different distribution of the active substance in the organs and tissues of the rabbit organism. Revealed a much larger and longer accumulation of the drug in the internal organs than in the muscles of animals by liquid chromatography. The maximum amount of the drug is determined in the back muscles (0.122 ± 0.003 mg/kg), tongue (0.125 ± 0.002 mg/kg), liver (0.130 ± 0.006 mg/kg), spleen (0.145 ± 0.005 mg/kg) and somewhat less muscles of the hip and shoulder girdle, kidneys, heart, lungs, brain, lymph nodes and traces in adipose tissue 14 days after administration to animals.The high concentration of the drug was noted in the muscles of the back (0,024 ± 0,005 mg/kg), the liver (0,023 ± 0,003 mg/kg) and the spleen (0,065 ± 0,007 mg/kg), but it was observed in other muscles, tongue, kidneys, heart, lungs, brain and lymph nodes after 21 days.The remnants of ivermectin were completely absent in samples of tissues and organs for 28 days.

Therefore, after using the drug, it is prohibited to use rabbit meat for food purposes for 28 days.